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Smoldering Multiple Myeloma

Smoldering Multiple Myeloma (SMM) app is a mobile application allowing healthcare professionals to calculate the SMM risk level on the basis of an algorithm combining the following parameters:

Smoldering Multiple Myeloma (SMM) app is a mobile application allowing healthcare professionals to calculate the SMM risk level on the basis of an algorithm combining the following parameters:

Smoldering Multiple Myeloma

by Pethema
Smoldering Multiple Myeloma
Smoldering Multiple Myeloma
Smoldering Multiple Myeloma

What is it about?

Smoldering Multiple Myeloma (SMM) app is a mobile application allowing healthcare professionals to calculate the SMM risk level on the basis of an algorithm combining the following parameters:

Smoldering Multiple Myeloma

App Details

Version
1.03
Rating
NA
Size
19Mb
Genre
Medical
Last updated
January 23, 2019
Release date
June 21, 2018
More info

App Screenshots

Smoldering Multiple Myeloma screenshot-0
Smoldering Multiple Myeloma screenshot-1
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Smoldering Multiple Myeloma screenshot-3

App Store Description

Smoldering Multiple Myeloma (SMM) app is a mobile application allowing healthcare professionals to calculate the SMM risk level on the basis of an algorithm combining the following parameters:
(1) Percentage of bone marrow plasma cell (BMPC) infiltration;
(2) Immunoglobulin level (based on either IgG level, IgA level, or Bence Jones (BJ) protein level);
(3) Percentage of phenotypically aberrant plasma cells in the bone marrow plasma cell compartment;
(4) Percentage of reductions in one or two uninvolved immunoglobulins.

The way in which the above-listed parameters should be combined and the threshold values which they require are described as follows in the paper “Lenalidomide plus dexamethasone for high-risk Smoldering Multiple Myeloma”, published by Mateos (et al.) in the New England Journal of Medicine (2013, 369:438-447):
“High-risk disease was defined as plasma-cell bone marrow infiltration of at least 10% and a monoclonal component (defined as an IgG level of ≥3 g per deciliter, an IgA level of ≥2 g per deciliter, or a urinary Bence Jones protein level of >1 g per 24 hours) or only one of the two criteria described above, plus at least 95% phenotypically aberrant plasma cells in the bone marrow plasma-cell compartment, with reductions in one or two uninvolved immunoglobulins of more than 25%, as compared with normal values”.

On the basis of the above-described parameters and values, resulting from blood tests and urinary tests (BJ index), the SMM app will calculate whether a patient is “high risk SMM”, “not high risk SMM”, or has progressed to MM (Multiple Myeloma).

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