iTIVA Anesthesia Plus

iTIVA is a pharmacokinetic/pharmacodynamic simulation application that estimates the plasma concentration of drugs based on mathematical models and simulates the behavior of a TCI (Target Controlled Infusion) pump, calculating an infusion scheme to reach and maintain a set target concentration, either in plasma or effect site. These schemes can be implemented in volumetric infusion pumps and be guided using pharmacokinetic models, to make "manual TCI" or target guided infusions.

Pharmacokinetic models

iTIVA includes a library with 27 drugs, more than 67 pharmacokinetic models and 9 pharmacodynamic models to explore drug interactions, that are updated continuously when you subscribe*:

- Remifentanil (ULTIVA)
- Fentanyl

- Sufentanil

- Alfentanil

- Hydromorphone
- Morphine
- Ketamine
- Procaine
- Lidocaine

- Propofol
 (DIPRIVAN)
- Etomidate
- Dexmedetomidine (PRECEDEX)
- Midazolam

- Remimazolam
- Thiopental
- Atracurium
- Cisatracurium
- Rocuronium
- Vecuronium
- Tranexamic

- Magnesium sulfate
- Diazepam
- Heparin - ACT estimation
- Protamine

This app also calculates the end-tidal (Et) concentration for a set MAC age for Isoflurane, Sevoflurane, and Desflurane, using the Mapleson equation.

- Record intraoperative milestones (like unconsciousness, BIS value, etc..)
- Share your case with other colleagues using QR codes
- Save your simulation cases to review them later, share with colleagues (e-mail, WhatsApp or AirDrop) or run multiple simulations at time.
- Export all recorded information as an excel file

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*iTIVA full access for a year

Additional features are available when you subscribe to iTIVA yearly, this optional paid subscription service funds the app’s development and allows full access to the main features of this App:
- Access to new PK / PD models published in the literature that are updated as they become available.
- Ask to include new models
- Simulates up to 7 drug drugs at a time
- Unlimited simulations without time restriction
- Export your case data to an XLS file
- 24 hrs support

iTIVA's yearly subscription is available for US$9,99/year. The subscription will be charged to iTunes Account at confirmation of purchase
• Subscription automatically renews unless auto-renew is turned off at least 24-hours before the end of the current period
• The account will be charged for renewal within 24-hours before the end of the current period, and identify the cost of the renewal
• Subscriptions may be managed by the user and auto-renewal may be turned off by going to the user's Account Settings after purchase
• Any unused portion of a free trial period, if offered, will be forfeited when the user purchases a subscription to that publication, where applicable

More details can be found here
iTIVA Privacy Policy: https://itiva.co/privacy.html
Terms and Conditions: http://itiva.co/terms.html