ACTPlus

This application has been used for over ten years in a cardiac catheterisation laboratory to achieve a desired activated clotting time (ACT) within the range of 300 - 400 seconds after a single dose of heparin over 86% of the time. If the Act falls short, it can be used to reliably give the next dose that will achieve the desired result. At completion of the procedure, it reliably indicates a dose of protamine that will return the ACT to the pre-heparin state. It has also been used to identify the dos elf heparin nd protamine in a small cardiac bypass series. The following references are available:

1. Cumpston P, Phillips KP. A Novel Method for Calculating Heparin Dosing to Rapidly Achieve Target Anticoagulation for Cardiac Procedures. Journal of Atrial Fibrillation. 2024;18.

2. Cumpston P. Blood volume estimation in cardiac surgery – A comparative analysis. Perfusion [Internet]. 2023 Apr [cited 2024 Mar 29];38(3):455–63. Available from: http://journals.sagepub.com/doi/10.1177/02676591211069920